NMR-based metabolomics Laboratory of Sapienza
Coordinates
41.9036428022199, 12.514534957176009
Contact name
Federico Marini
CIVIS Label
Yes
Acronym
NMLab-SRI
Scientific domain
LS2_9 - Metabolomics - Integrative Biology: from Genes and Genomes to Systems
Keywords
1H NMR-based metabolomics
Partner institution
Sapienza Università di Roma
Website
No
Technical staff available
No
Remote access details
The research service is agreed upon according to specific needs. Requests for access to the research service must be sent by email to nmlab.sapienza@uniroma1.it
Remote access available
No
Open to external users
No
Equipment
Metabolomics and Metagenomics to investigate the development of gut microbiome in the infants; Interaction between host and gut microbiome in the modulation of the response to biological cancer therapy; Role of gut microbiome in the NAFLD and cirrhosis. Responsibles: Miccheli A., OPBG, Gemelli
Research Project agreement with Agricultural Company Aureli Mario: B.I.C.Y. (Biostimulants increase crops yield) to realize and to conduct the activities in the Project “Fabbrica intelligente, Agrifood e Scienze della vitaâ€ù Ministero dello Sviluppo Economico, Programma Operativo Nazionale «Imprese e Competitività» 2014-2020 FESR.
AIRC research project: Environmental stimuli shape microglial plasticity in glioma: responsable: Cristina Limatola
Sustainable cultivation of the medicinal plant Hypericum perforatum (L.): saprotiferous mushrooms of the soil for the promotion of growth and the induction of resistance (University Research Project 2018, Department of Environmental Biology). Responsible: Prof. A. M. Persiani,
Study of the metagenomic and metabolomic profiles of the intestinal microbiota and intestinal immunological network in children with Crohn's disease
Identification and characterization of new epigenetic factors and metabolic control (University Research Project 2018, Department of Biology and Biotechnology "Charles Darwin"). Uccelletti D. and Miccheli A.
Innovative strategies for quality milk (StraLaQ). MIPAFPT "MILK FUND" PROJECTS D.M. n. 27443 OF 09/25/2018. Responsible: Prof Stefano Materazzi. Department of Sapienza Chemistry - Department of Veterinary Medicine UNIMI.
Research contract with Azienda Agricola M. Aureli within the realization objectives of the project Sustainable innovation for quality food production - INNOPAQ: within the POR FESR Abruzzo 2014-2020 projects: Action lines 1.1.1 and 1.1.4 . Title of the research project: "Application of innovative analytical techniques for the optimization of the process phases: collection, transformation and conservation of vegetable products". Responsible: prof. Alfredo Miccheli.
Research Contract with Azienda Agricola M. Aureli "Development of new plant foods functional to the well-being of health and new food sanitization processes". Responsible: prof. Alfredo Miccheli
Open access to updated information database
No
Online booking system details
https://www.chem.uniroma1.it/nmlab/sites/default/files/download/NMLab_regolamento_e_tariffario.pdf
Online booking system available
No
Description
The main activities of the Laboratory are:
Characterization of the metabolic profiles (phenotypes) of plant and animal living organisms;
Characterization of the metabolic profiles of microbial, plant, animal and human cells in relation to genetic mutations or biotic or abiotic perturbations;
Identification of new biomarkers to improve clinical diagnosis and prognosis;
Identification of new metabolic targets in different human pathologies;
Evaluation of the effect of pharmacological, dietary or behavioral interventions on human and animal health;
Evaluation of possible side effects of drug treatments;
Evaluation of the interactions among diet, intestinal microbiota and human and animal metabolism in physiological and pathological states;
Customization of pharmacological and/or nutritional interventions on the basis of the metabolic phenotype of the individual (Precision Medicine and Nutrition);
Carrying out the integrated characterization of plant foods in relation to origin, soil and climatic and agronomic conditions;
Identification of bioactive compounds in food;
Designing functional foods and evaluation of their impact on health;
Evaluation of the steps of transformation of food products for process optimization;
Evaluation of the steps of processes involved in the circular agricultural economy.
The laboratory provides the necessary structures and skills for the preparation of samples for metabolomics analysis, acquisition of spectra, their processing and subsequent data analysis.
The characteristics of the JNM-ECZ 600R spectrometer do not limit its application to metabolomic analysis only, but rather allow its use in numerous other research topics such as, for example, the determination of molecular structure, the composition of mixtures and every application where high resolution mono and two-dimensional NMR spectra are needed.