1. Research Infrastructures
  2. in vivo animal and human MRI platform

in vivo animal and human MRI platform

CONTACT
Coordinates 43.29236346203756, 5.359133426541125
Contact name Monique Bernard
CIVIS Label No
Acronym PhenoMars-CriBiom-PTA
Scientific domain

LS4_1 - Organ and tissue physiology and pathophysiology - Physiology in Health, Disease and Ageing


 

LS7_1 - Medical imaging for prevention, diagnosis and monitoring of diseases - Prevention, Diagnosis and Treatment of Human Diseases


 

LS5_3 - Neural development and related disorders - Neuroscience and Disorders of the Nervous System


Keywords

MRI


 

In vivo imaging


 

magnetic resonance


 

spectroscopy


 

pre-clinical imaging


 

clinical imaging


 

central nervous system


 

cardiovascular system


 

musculoskeletal system


 

physiopathology


 

diagnosis


 

therapeutic follow-up.


Partner institution

Aix-Marseille Université


Website No
Technical staff available No
Remote access details PhenoMars is open to scientific communities from both the academic and private sectors, upon request. Requests to use the facility's equipments must be sent to the scientific manager (monique.bernard@univ-amu.fr) or eventually the technical manager (s.confort-gouny@univ-amu.fr) by email. They can be sent throughout the year and will eventually be selected on the basis of their feasibility, also taking into account the time and human resources they imply. A description of the project is necessary to provide, notably specifying the imaging modality (clinical or pre-clinical MRI), the magnetic field, the type of study (mono-centric or multi-center), the number of subjects, the regulatory constraints, the time constraints (supported or not by extra non-confidential documents), and the framework of the request (scientific or commercial partnership). In principle, a response is given to the applicants in the two following months of the request, along with a quote and provisional schedule.
Remote access available No
Open to external users No
Equipment PhenoMars is open to collaborative work and provides services in magnetic resonance imaging and spectroscopy, with particular expertise in: 1-the central nervous system (brain and spinal cord), 2-the cardiovascular system (heart and aorta), 3-the musculoskeletal system (muscle, cartilage, and bone). In addition to that, the facility is also able to respond to specific requests (e.g., in oncology, liver disease). Magnetic resonance explorations include morphological, metabolic, and functional imaging. Advanced explorations are also possible thanks to the developments made by the on-site research teams. It can for instance offer multi-nucleus explorations (phosphorus-31 (31P), sodium-23 (23Na)), advanced methods for brain, cardiac perfusion, spinal cord and myelin imaging. The facility is precisely equipped with 8 MR systems notably including: -2 high resolution multinuclear Bruker MR wide bore spectrometers at 200 MHz (4.7T) and 400 MHz (9.4T) to study of biological fluids, cell extracts, and perfused organs (muscle, heart), -a Bruker Biospec Avance 47/30 MRI/MRS system (4.7T horizontal magnet) to study small animal in vivo imaging, -a Bruker Avance 500 WB system (11.75T) dedicated to MRI/MRS of transgenic mice, including micro-imaging, -a Bruker USR 70/16 (7T) equipped with a cryoprobe for rodent studies. Moreover, all magnets are equipped with radiofrequency probes for body, brain, spinal cord, muscle, and cardio-vascular studies. Finally, the facility also includes (among others): -animal facilities for rats and mice with space to prepare the animals for MR exams, -an equipped surgery room and a wide assortment of ancillary equipment, i.e. anesthesia machines, MR compatible physiological monitoring, infusion pumps, and heating pads, -equipment for animal exercising, -homemade systems for muscle stimulations during MR exploration.
Open access to updated information database No
Online booking system details Charte des Plateformes Technologiques Aix-Marseille (PTA): https://www.univ-amu.fr/system/files/2021-07/Charte%20PTF%20AMU%20M%C3%A0J21.docx.pdf
Online booking system available No
Description PhenoMars is dedicated to developing and applying magnetic resonance methods and instruments for morphologic, metabolic and functional exploration of small animal models (mostly rodents) and humans. The facilty is hosted at the UMR 7339 and is jointly operated by the CNRS and the University of Aix-Marseille under a contractual agreement with the Assistance Publique – Hôpitaux de Marseille (AP-HM). PhenoMars also benefits from being located next to the preclinical and human equipments of the University Hospital Center 'La Timone' in Marseille, which is recognised to be one of the largest medical campuses and hospitals in southern Europe.