Centre d'Imunophénomique

CIPHE is a facility hosted at the INSERM US12/CNRS/Aix-Marseille Université UMS3367 research unit. 
The facility is dedicated to create innovative customized mouse models to be delivered under a specified and opportunistic pathogen free status (SOPF). 
CIPHE notably allows analyzing the immune system of the mouse under normal and infectious conditions. 
Thanks to its expertise at the crossroads between mouse genetics and immunology, CIPHE actively contributes to the research advances in knock-in and knock-out mouse models to understand the nature of the "molecular machines" that determine the function of the cells participating to the immune system.

CIPHE is open to scientific communities of both the academic and private sectors, upon request. 
Requests can be submitted via the following web portal: http://www.phenomin.fr/en-us/scientific-context/infrastructure/, according to the PHENOMIN French National Infrastructure rules of which CIPHE takes part.

Into details, CIPHE offers access to the following equipments and associated analysis methods: 

• knock-in/knock-out booster, -microinjection and cryopreservation unit, 
• immunophenotyping unit, 
• BSL3 facility capable of in vivo non-invasive imaging of infectious processes, 
• SPF animal house. 

By using multiparametric flow and mass cytometry, as well as advanced microscopy approaches, CIPHE has the unique ability to decipher the complexity of the immune system at the systemic level, using up to 300 quantitative parameters.