1. Research Infrastructures
  2. Screening platform for bacteria

Screening platform for bacteria

CONTACT
Coordinates 43.29236346203756, 5.359133426541125
Contact name Véronique Sinou
CIVIS Label No
Acronym BACSCREEN-PTA
Scientific domain

LS9_4 - Microbial biotechnology and bioengineering - Biotechnology and Biosystems Engineering


 

LS7_1 - Medical imaging for prevention, diagnosis and monitoring of diseases - Prevention, Diagnosis and Treatment of Human Diseases


 

LS1_2 - Biochemistry - Molecules of Life: Biological Mechanisms, Structures and Functions


Keywords

High content screening


 

Bacteria


 

Antibiotic resistance


 

Membranes


 

Drug-design


 

Biofilms


Partner institution

Aix-Marseille Université


Website No
Technical staff available No
Remote access details BACSREEN is open to both public and private research laboratories, including industries. The experiments can be performed by the platform staff or by external users themselves upon assistance and after being trained on the tools by the local staff. A biosafety level 2 on bacteria is requested. Note that the molecules for screening are provided in micro-titerplate (liquid form) or mictrotube (liquid or solid form), which implies skilled users in the matter.
Remote access available No
Open to external users No
Equipment Precisely, BACSREEN offers the following services: -in cellulo-screening on planctonic bacteria and bacterial biofilms, -pharmacomodulations, -implementation of assays to assess the integrity of bacteria membrane and of porin and efflux pump activities, -optimization of "hit" molecules (“hit" to "lead strategy"), -access to microbial culture collection strains/clinical isolates, -access to chemical libraries.
Open access to updated information database No
Online booking system details Charte des Plateformes Technologiques Aix-Marseille (PTA): https://www.univ-amu.fr/system/files/2021-07/Charte%20PTF%20AMU%20M%C3%A0J21.docx.pdf
Online booking system available No
Description BACSCREEN first missions are to identify and analyze new antibacterial agents or adjuvants that potentiate the activity of existing antibiotics, in the puropose to understand their mechanisms of action. The main services os the facility are phenotypic screening and the optimization of "hit" molecules, as well as the development of activity tests in relation with the membrane integrity and efflux.