pMedGR aims to become a regional hub for the implementation, coordination and integration of personalized medicine approaches in South-East Europe, as part of a global network, offering centralized information on patient stratification, susceptibility factors and response to treatments for relevant regional populations. This hub will serve as a single entry point for researchers and industry with an interest in targeting this area. Greece’s strategic geopolitical position, which correlates with genetic characteristics that may be important to health and disease, render it ideal to serve as a paradigm for personalized approaches targeting an extended regional area, including south Italy, the Balkans, Turkey etc. Through pMedGR, Greece has the potential to become a South-East European Node for Personalized Medicine, linking Europe to emerging markets such as Asia, Africa and the Middle East.