BACSCREEN first missions are to identify and analyze new antibacterial agents or adjuvants that potentiate the activity of existing antibiotics, in the puropose to understand their mechanisms of action. 
The main services os the facility are phenotypic screening and the optimization of "hit" molecules, as well as the development of activity tests in relation with the membrane integrity and efflux.

Description

BACSCREEN first missions are to identify and analyze new antibacterial agents or adjuvants that potentiate the activity of existing antibiotics, in the puropose to understand their mechanisms of action. 
The main services os the facility are phenotypic screening and the optimization of "hit" molecules, as well as the development of activity tests in relation with the membrane integrity and efflux.

Partner institution

Aix-Marseille Université

Scientific domain

LS9_4 - Microbial biotechnology and bioengineering - Biotechnology and Biosystems Engineering LS7_1 - Medical imaging for prevention, diagnosis and monitoring of diseases - Prevention, Diagnosis and Treatment of Human Diseases LS1_2 - Biochemistry - Molecules of Life: Biological Mechanisms, Structures and Functions

Keywords

High content screening Bacteria Antibiotic resistance Membranes Drug-design Biofilms